Recombinant Mouse Clstn1 Protein, Myc/DDK-tagged

• Cat.No.: Clstn1-2198M
• Product Overview: Purified recombinant protein of mouse full-length calsyntenin 1 (Clstn1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.
• Molecular Mass: 109.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Clstn1 calsyntenin 1 [ Mus musculus (house mouse) ]
• Official Symbol: Clstn1
• Synonyms: CLSTN1; calsyntenin 1; calsyntenin-1; alc-alpha; alcadein alpha; alcadein-alpha; Cst-1; Cstn1; 1810034E21Rik
• Gene ID: 65945
• mRNA Refseq: NM_023051
• Protein Refseq: NP_075538
• UniProt ID: Q9EPL2