Recombinant Mouse Cpe Protein, MYC/DDK-tagged

• Cat.No.: Cpe-931M
• Product Overview: Purified recombinant protein of full-length mouse carboxypeptidase E (Cpe), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 53.7 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cpe carboxypeptidase E [ Mus musculus (house mouse) ]
• Official Symbol: Cpe
• Synonyms: Cpe; carboxypeptidase E; CPH; fat; Cph1; Cph-1; R74677; NF-alpha1; carboxypeptidase E; carboxypeptidase H; enkephalin convertase; prohormone-processing carboxypeptidase; EC 3.4.17.10
• Gene ID: 12876
• mRNA Refseq: NM_013494
• Protein Refseq: NP_038522
• UniProt ID: Q00493