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Recombinant Mouse Cul2 Protein, Myc/DDK-tagged

Cat.No. : Cul2-2375M
Product Overview : Purified recombinant protein of mouse full-length cullin 2 (cDNA clone MGC:25783 IMAGE:4018298), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 86.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Cul2 cullin 2 [ Mus musculus (house mouse) ]
Official Symbol : Cul2
Synonyms : CUL2; cullin 2; cullin-2; CUL-2; AI327301; mKIAA4106; 1300003D18Rik; 4932411N15Rik; KIAA4106
Gene ID : 71745
mRNA Refseq : NM_029402
Protein Refseq : NP_083678
UniProt ID : Q9D4H8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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