Recombinant Mouse Dnajc2 Protein, Myc/DDK-tagged

• Cat.No.: Dnajc2-2607M
• Product Overview: Purified recombinant protein of mouse full-length DnaJ heat shock protein family (Hsp40) member C2 (Dnajc2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 71.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 [ Mus musculus (house mouse) ]
• Official Symbol: Dnajc2
• Synonyms: DNAJC2; DnaJ (Hsp40) homolog, subfamily C, member 2; dnaJ homolog subfamily C member 2; Id associate 1; zuotin related factor 1; zuotin related factor 2; zuotin-related factor 1; Zrf1; Zrf2; MIDA1; AU020218
• Gene ID: 22791
• mRNA Refseq: NM_009584
• Protein Refseq: NP_033610
• UniProt ID: P54103