Recombinant Mouse Dpy30 Protein, Myc/DDK-tagged

• Cat.No.: Dpy30-2648M
• Product Overview: Purified recombinant protein of mouse full-length dpy-30, histone methyltransferase complex regulatory subunit (Dpy30), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play an indirect or direct role in endosomal transport.
• Molecular Mass: 11.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dpy30 dpy-30, histone methyltransferase complex regulatory subunit [ Mus musculus (house mouse) ]
• Official Symbol: Dpy30
• Synonyms: DPY30; dpy-30 homolog (C. elegans); protein dpy-30 homolog; dpy-30L; dpy-30-like protein; dosage compensation-related protein DPY30; C87842; 2810410M20Rik
• Gene ID: 66310
• mRNA Refseq: NM_001146224
• Protein Refseq: NP_001139696
• UniProt ID: Q99LT0