Recombinant Mouse Dr1 Protein, Myc/DDK-tagged

• Cat.No.: Dr1-2656M
• Product Overview: Purified recombinant protein of mouse full-length down-regulator of transcription 1 (Dr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 19.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dr1 down-regulator of transcription 1 [ Mus musculus (house mouse) ]
• Official Symbol: Dr1
• Synonyms: DR1; down-regulator of transcription 1; protein Dr1; NC2-beta; negative cofactor 2-beta; TATA-binding protein-associated phosphoprotein; NC2; Dr1l; NC2beta; 1700121L09Rik
• Gene ID: 13486
• mRNA Refseq: NM_026106
• Protein Refseq: NP_080382
• UniProt ID: Q91WV0