Recombinant Mouse Eif4ebp2 Protein, Myc/DDK-tagged

• Cat.No.: Eif4ebp2-2788M
• Product Overview: Purified recombinant protein of mouse full-length eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 12.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 [ Mus musculus (house mouse) ]
• Official Symbol: Eif4ebp2
• Synonyms: EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2; eukaryotic translation initiation factor 4E-binding protein 2; eIF4E-binding protein 2; phosphorylated heat- and acid-stable protein regulated by insulin 2; 4E-BP2; PHAS-II; AA792569; BC010348; 2810011I19Rik; MGC141219
• Gene ID: 13688
• mRNA Refseq: NM_010124
• Protein Refseq: NP_034254
• UniProt ID: P70445