Recombinant Mouse Erap1 Protein, Myc/DDK-tagged
Cat.No. : | Erap1-2851M |
Product Overview : | Purified recombinant protein of mouse full-length endoplasmic reticulum aminopeptidase 1 (Erap1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 107 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Erap1 endoplasmic reticulum aminopeptidase 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Erap1 |
Synonyms : | ERAP1; endoplasmic reticulum aminopeptidase 1; A-LAP; ARTS-1; PILS-AP; aminopeptidase PILS; VEGF-induced aminopeptidase; adipocyte-derived leucine aminopeptidase; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; Arts1; ERAAP; PILSA; PILSAP |
Gene ID : | 80898 |
mRNA Refseq : | NM_030711 |
Protein Refseq : | NP_109636 |
UniProt ID : | Q9EQH2 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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