Recombinant Mouse Fam107a Protein, Myc/DDK-tagged

• Cat.No.: Fam107a-2909M
• Product Overview: Purified recombinant protein of mouse full-length family with sequence similarity 107, member A (Fam107a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 17.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fam107a family with sequence similarity 107, member A [ Mus musculus (house mouse) ]
• Official Symbol: Fam107a
• Synonyms: FAM107A; family with sequence similarity 107, member A; protein FAM107A; DRR1; RP24-111B7.1; MGC58343
• Gene ID: 268709
• mRNA Refseq: NM_183187
• Protein Refseq: NP_899010
• UniProt ID: Q78TU8