Recombinant Mouse Fap protein, His-SUMO-tagged

• Cat.No.: Fap-2373M
• Product Overview: Recombinant Mouse Fap protein(P97321)(26-761aa), fused to N-terminal His-SUMO tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His&SUMO
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 101.3 kDa
• Protein length: 26-761aa
• AA Sequence: LRPSRVYKPEGNTKRALTLKDILNG TFSYKTYFPNWISEQEYLHQSEDDN IVFYNIETRESYIILSNSTMKSVNA TDYGLSPDRQFVYLESDYSKLWRYS YTATYYIYDLQNGEFVRGYELPRPI QYLCWSPVGSKLAYVYQNNIYLKQR PGDPPFQITYTGRENRIFNGIPDWV YEEEMLATKYALWWSPDGKFLAYVE FNDSDIPIIAYSYYGDGQYPRTINI PYPKAGAKNPVVRVFIVDTTYPHHV GPMEVPVPEMIASSDYYFSWLTWVS SERVCLQWLKRVQNVSVLSICDFRE DWHAWECPKNQEHVEESRTGWAGGF FVSTPAFSQDATSYYKIFSDKDGYK HIHYIKDTVENAIQITSGKWEAIYI FRVTQDSLFYSSNEFEGYPGRRNIY RISIGNSPPSKKCVTCHLRKERCQY YTASFSYKAKYYALVCYGPGLPIST LHDGRTDQEIQVLEENKELENSLRN IQLPKVEIKKLKDGGLTFWYKMILP PQFDRSKKYPLLIQVYGGPCSQSVK SVFAVNWITYLASKEGIVIALVDGR GTAFQGDKFLHAVYRKLGVYEVEDQ LTAVRKFIEMGFIDEERIAIWGWSY GGYVSSLALASGTGLFKCGIAVAPV SSWEYYASIYSERFMGLPTKDDNLE HYKNSTVMARAEYFRNVDYLLIHGT ADDNVHFQNSAQIAKALVNAQVDFQ AMWYSDQNHGISSGRSQNHLYTHMT HFLKQCFSLSD
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Gene Information

• Gene Name: Fap fibroblast activation protein [ Mus musculus ]
• Official Symbol: Fap
• Synonyms: FAP; fibroblast activation protein; seprase; integral membrane serine protease; fibroblast activation protein alpha
• Gene ID: 14089
• mRNA Refseq: NM_007986
• Protein Refseq: NP_032012

Reviews

08/11/2020

It enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

05/04/2020

FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

01/02/2019

FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

Q&As

How does FAP contribute to immunosuppression in the tumor microenvironment?

FAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.

How can FAP expression be used as a prognostic marker in cancer patients?

High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.

Are there ongoing clinical trials exploring FAP-targeted therapies?

Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.

Can FAP be utilized as a therapeutic target beyond cancer treatment?

FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.

How is imaging technology utilized to detect FAP expression in tumors?

Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.