Recombinant Mouse Fen1 Protein, Myc/DDK-tagged
Cat.No. : | Fen1-2986M |
Product Overview : | Purified recombinant protein of mouse full-length flap structure specific endonuclease 1 (Fen1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 42.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Fen1 flap structure specific endonuclease 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Fen1 |
Synonyms : | FEN1; flap structure specific endonuclease 1; flap endonuclease 1; FEN-1; flap structure-specific endonuclease 1; AW538437 |
Gene ID : | 14156 |
mRNA Refseq : | NM_007999 |
Protein Refseq : | NP_032025 |
UniProt ID : | Q91Z50 |
Products Types
◆ Recombinant Protein | ||
FEN1-1509R | Recombinant Rhesus Macaque FEN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
FEN1-1971R | Recombinant Rat FEN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
FEN1-013H | Recombinant Human FEN1 Protein, His-tagged | +Inquiry |
FEN1-1236H | Recombinant Human FEN1 Protein (G2-K380), His/Strep tagged | +Inquiry |
FEN1-360H | Recombinant Human FEN1 protein(Met1~Thr195), His-tagged | +Inquiry |
◆ Lysates | ||
FEN1-6264HCL | Recombinant Human FEN1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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