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Recombinant Mouse Fhit Protein, Myc/DDK-tagged

Cat.No. : Fhit-3010M
Product Overview : Purified recombinant protein of mouse full-length fragile histidine triad gene (Fhit), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 17.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Fhit fragile histidine triad gene [ Mus musculus (house mouse) ]
Official Symbol : Fhit
Synonyms : FHIT; fragile histidine triad gene; bis(5-adenosyl)-triphosphatase; AP3Aase; AP3A hydrolase; dinucleosidetriphosphatase; fragile histidine triad protein; diadenosine triphosphate hydrolase; diadenosine 5,5-P1,P3-triphosphate hydrolase; Fra14A2; AW045638
Gene ID : 14198
mRNA Refseq : NM_010210
Protein Refseq : NP_034340
UniProt ID : O89106

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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