Recombinant Mouse Figla Protein, Myc/DDK-tagged

• Cat.No.: Figla-3016M
• Product Overview: Purified recombinant protein of mouse full-length folliculogenesis specific basic helix-loop-helix (Figla), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 22 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Figla folliculogenesis specific basic helix-loop-helix [ Mus musculus (house mouse) ]
• Official Symbol: Figla
• Synonyms: Figla; folliculogenesis specific basic helix-loop-helix; bHLHc; bHLHc8; FIGalpha; factor in the germline alpha; FIG alpha; transcription factor FIGa
• Gene ID: 26910
• mRNA Refseq: NM_012013
• Protein Refseq: NP_036143
• UniProt ID: O55208