Recombinant Mouse FMS-like Tyrosine Kinase 3
Cat.No. : | Flt3-500M |
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Species : | Mouse |
Source : | Mammalian Cells |
Tag : | Non |
Description : | Fms-Like tyrosine kinase 3 (FLT3) is a member of the class III tyrosine kinase receptor family, normally expressed in hematopoietic, immune and neural systems. FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin. FLT3 is a promising target for the therapeutic intervention for acute leukemias, particularly acute myeloid leukemia (AML) which are severe and aggressive malignancy. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse Flt-3 is Mr 85 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 116 kDa. |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name | Flt3 FMS-like tyrosine kinase 3 [ Mus musculus ] |
Synonyms | Flt3; FMS-like tyrosine kinase 3; Flk2; Ly72; CD135; Flk-2; Flt-3; MGC124377; MGC124378; B230315G04; OTTMUSP00000022189; EC 2.7.10.1 |
Gene ID | 14255 |
mRNA Refseq | NM_010229 |
Protein Refseq | NP_034359 |
UniProt ID | Q00342 |
Chromosome Location | 5 G3; 5 82.0 cM |
Pathway | Acute myeloid leukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer |
Function | ATP binding; kinase activity; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; protein kinase activity ; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity |
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Not For Human Consumption!
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