Recombinant Mouse Frmd8 Protein, Myc/DDK-tagged

• Cat.No.: Frmd8-3085M
• Product Overview: Purified recombinant protein of mouse full-length FERM domain containing 8 (Frmd8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 51.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Frmd8 FERM domain containing 8 [ Mus musculus (house mouse) ]
• Official Symbol: Frmd8
• Synonyms: FRMD8; FERM domain containing 8; FERM domain-containing protein 8; AU018809; 1200004M23Rik; 2310035N23Rik; 4931429L16Rik
• Gene ID: 67457
• mRNA Refseq: NM_026169
• Protein Refseq: NP_080445
• UniProt ID: Q3UFK8