Recombinant Mouse Fst Protein, Myc/DDK-tagged

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Recombinant Mouse Fst Protein, Myc/DDK-tagged

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Cat.No. : Fst-3092M
Product Overview : Purified recombinant protein of mouse full-length follistatin (Fst), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 38.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Fst follistatin [ Mus musculus (house mouse) ]
Official Symbol : Fst
Synonyms : Fst; follistatin; FS; D2Mgi5; AL033346; follistatin; activin-binding protein
Gene ID : 14313
mRNA Refseq : NM_008046
Protein Refseq : NP_032072
UniProt ID : P47931
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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