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Recombinant Mouse Glb1 Protein, MYC/DDK-tagged

Cat.No. : Glb1-706M
Product Overview : Purified recombinant protein of full-length mouse galactosidase, beta 1 (Glb1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a lysosomal enzyme that catalyzes the hydrolysis of terminal beta-D-galactose residues in various substrates like lactose, ganglioside GM1 and other glycoproteins. Mutations in the human gene are associated with GM1-gangliosidosis and Morquio B syndrome. Disruption of the mouse gene mirrors the symptoms of human gangliosidosis. Alternative splicing results in multiple transcript variants.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 73 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Glb1 galactosidase, beta 1 [ Mus musculus (house mouse) ]
Official Symbol : Glb1
Synonyms : Glb1; galactosidase, beta 1; Bge; Bgl; Bgs; Bgt; Bgl-e; Bgl-s; Bgl-t; AW125515; C130097A14Rik; beta-galactosidase; acid beta-galactosidase; lactase; EC 3.2.1.23
Gene ID : 12091
mRNA Refseq : NM_009752
Protein Refseq : NP_033882
UniProt ID : P23780

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does GLB1 protein deficiency impact the nervous system? 07/04/2022

GLB1 deficiency can lead to neurodegeneration, causing progressive deterioration of the nervous system.

What are the different subtypes of GLB1 deficiency? 02/15/2020

There are three subtypes: GM1 gangliosidosis, mucopolysaccharidosis IVB, and combined GM1 gangliosidosis and mucopolysaccharidosis IVB.

Can GLB1 deficiency be managed through dietary interventions? 12/11/2019

While dietary interventions may help manage certain symptoms, they do not address the underlying cause of the deficiency.

What are the symptoms of GLB1 deficiency? 08/29/2018

Symptoms may include developmental delay, skeletal abnormalities, vision and hearing loss, and neurological deterioration.

Can GLB1 deficiency be detected prenatally? 05/21/2016

Yes, prenatal testing through genetic analysis of amniotic fluid or chorionic villus sampling can detect GLB1 deficiency.

Customer Reviews (3)

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Reviews
12/10/2021

    Their support has been invaluable in troubleshooting and providing efficient solutions, enhancing the overall efficiency and productivity of my experiments.

    04/03/2019

      Its versatility allows for exploring its various roles and functions, shedding light on its significance in crucial biochemical pathways and cellular processes.

      05/16/2016

        Their knowledgeable and responsive team has consistently demonstrated their ability to address any concerns or challenges I have encountered along the way.

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