Recombinant Mouse Gldn Protein, Myc/DDK-tagged

• Cat.No.: Gldn-3222M
• Product Overview: Purified recombinant protein of mouse full-length gliomedin (Gldn), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 59.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Gldn gliomedin [ Mus musculus (house mouse) ]
• Official Symbol: Gldn
• Synonyms: GLDN; gliomedin; collomin; olfactomedin-related protein; cancer related gene - liver 2; cancer-related gene liver 2 protein; Clom; Colm; Crgl2; Crlg2; CRG-L2
• Gene ID: 235379
• mRNA Refseq: NM_177350
• Protein Refseq: NP_796324
• UniProt ID: Q8BMF8