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Recombinant Mouse Hspa8 Protein, MYC/DDK-tagged

Cat.No. : Hspa8-1174M
Product Overview : Purified recombinant protein of full-length mouse heat shock protein 8 (cDNA clone MGC:102008 IMAGE:30540914), complete cds, with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
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Description : Ubiquitous expression in placenta adult (RPKM 956.1), CNS E11.5 (RPKM 802.7) and 28 other tissues
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 70.9 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Hspa8 heat shock protein 8 [ Mus musculus (house mouse) ]
Official Symbol : Hspa8
Synonyms : Hspa8; heat shock protein 8; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; 2410008N15Rik; heat shock cognate 71 kDa protein; heat shock 70 kDa protein 8; heat shock cognate hsc73; heat shock protein cognate 70
Gene ID : 15481
mRNA Refseq : NM_031165
Protein Refseq : NP_112442
UniProt ID : P63017

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In the context of cellular stress, how does HSPA8 contribute to the heat shock response, and what downstream signaling pathways does it modulate to promote cell survival? 03/14/2022

HSPA8 is a central player in the heat shock response, assisting in the refolding of denatured proteins. It modulates downstream pathways such as HSF1 activation, orchestrating a cellular survival response.

Can you discuss the involvement of HSPA8 in neurodegenerative diseases, and how does its chaperone activity influence protein aggregation and neuronal dysfunction? 10/03/2021

HSPA8 plays a role in neurodegenerative diseases, mitigating protein aggregation and neuronal dysfunction. Its chaperone activity is crucial for maintaining protein homeostasis in the nervous system.

How does HSPA8 participate in the regulation of apoptosis, and what anti-apoptotic mechanisms does it employ to maintain cellular viability under stress conditions? 04/11/2020

HSPA8 exhibits anti-apoptotic functions by interacting with pro-apoptotic proteins and preventing their activation. Its role in apoptosis regulation contributes to cell survival during stress.

What is the significance of HSPA8 in autophagy, and how does it influence the selective degradation of misfolded proteins and damaged organelles? 09/27/2019

HSPA8 is involved in autophagy, facilitating the clearance of misfolded proteins and damaged organelles. It interacts with autophagy receptors, promoting their recognition by autophagosomes.

What are the mechanisms by which HSPA8 regulates the immune response, particularly its involvement in antigen presentation and the modulation of immune cell functions? 07/22/2018

HSPA8 participates in antigen presentation and modulates immune cell functions. It chaperones antigens for presentation on major histocompatibility complexes, influencing immune recognition and response.

Customer Reviews (3)

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Reviews
12/01/2021

    The lab product's precision and quality are noteworthy.

    10/25/2020

      The customer service team was accommodating, and the delivery exceeded my expectations.

      05/10/2018

        This lab product is synonymous with excellence.

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