Recombinant Mouse Il12b, Fc-tagged
Cat.No. : | Il12b-348M |
Product Overview : | The mouse IL-23 complex composed of the p40 subunit (aa 23-335) and the p19 subunit (aa 20-196) is fused through a polypeptide linker to the Fc region of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 Rbeta1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma; production by human T cells. While IL-12 acts on both naie and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8-and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide. |
Source : | CHO Cells |
Species : | Mouse |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | Il12b interleukin 12b [ Mus musculus ] |
Official Symbol : | Il12b |
Synonyms : | IL12B; interleukin 12b; interleukin-12 subunit beta; CLMF p40; IL-12 p40; IL-12 subunit p40; IL-23 subunit p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; p40; Il-12b; Il12p40; Il-12p40; |
Gene ID : | 16160 |
mRNA Refseq : | NM_008352 |
Protein Refseq : | NP_032378 |
Pathway : | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; |
Function : | contributes_to cytokine activity; cytokine receptor activity; contributes_to cytokine receptor binding; identical protein binding; interleukin-12 alpha subunit binding; interleukin-12 alpha subunit binding; protein binding; protein heterodimerization activity; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
IL12B-145H | Active Recombinant Human IL12B protein(Met1-Ser328), His-tagged | +Inquiry |
IL12B-502H | Recombinant Human IL12B Protein | +Inquiry |
IL12B-1381M | Acitve Recombinant Marmoset IL12B protein(Met1-Asn328), hFc-tagged | +Inquiry |
IL12B-181I | Active Recombinant Human IL12B Protein | +Inquiry |
IL12B-1001C | Recombinant Chicken IL12B Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL12B-1000MCL | Recombinant Marmoset IL12B cell lysate | +Inquiry |
IL12B-1101MCL | Recombinant Mouse IL12B cell lysate | +Inquiry |
IL12B-2731HCL | Recombinant Human IL12B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket