Recombinant Mouse Il36a Protein, Myc/DDK-tagged
|Product Overview :||Purified recombinant protein of mouse full-length interleukin 1 family, member 6 (Il1f6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.|
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|Description :||Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T-cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells. May be involved in CD4+ T-cell proliferation. Induces NF-kappa B activation in macrophages.|
|Molecular Mass :||18.5 kDa|
|Purity :||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Stability :||Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.|
|Storage :||Store at -80 centigrade after receiving vials.|
|Concentration :||>50 μg/mL as determined by microplate BCA method|
|Storage Buffer :||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.|
|Gene Name :||Il36a interleukin 36A [ Mus musculus (house mouse) ]|
|Official Symbol :||Il36a|
|Synonyms :||IL1F6; interleukin 1 family, member 6; interleukin-36 alpha; IL-1F6; Fil1epsilon; FIL1 epsilon; IL-1 epsilon; interleukin-1 epsilon; interleukin-1 homolog 1; interleukin-1 family member 6; interleukin 1 family, member 9; interleukin 1 family, member 6 (epsilon); Fil1; Il1f9; Il36a; IL-1H1; IL1RP2; MGC151479; MGC151481|
|Gene ID :||54448|
|mRNA Refseq :||NM_019450|
|Protein Refseq :||NP_062323|
|UniProt ID :||Q9JLA2|
|IL36A-5238HCL||Recombinant Human IL1F6 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
In general, the use of IL36A does not cause significant fever reactions, but individual differences exist, if there are abnormalities, please consult a doctor.
The IL36A is expressed, purified, and constructed using recombinant DNA technology in a suitable host expression system, usually through genetic engineering.
IL36A has potential application value in psoriasis, arthritis and other inflammatory diseases, but the specific efficacy needs further study.
IL36A has been shown in some studies to have anti-proliferative and anti-invasive effects on certain tumors, but more studies are needed to confirm its specific mechanism of action and effect.
The research of IL36A is progressing continuously, and some studies have shown its potential in immune regulation, anti-inflammatory effect and so on.
Yes, IL36A can be used in animal studies to investigate its mechanism of action and potential applications.
Customer Reviews (3)Write a review
Western blot can simultaneously detect the purity and specificity of IL-36A. -
The purity of IL-36A can be preliminarily detected by SDS-PAGE electrophoresis and verified and quantified according to molecular weight. -
Infrared spectroscopy can be used to detect the structural characteristics of IL-36A, such as the main structure of the protein and the interaction of amino acid residues. -
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