Recombinant Mouse Inducible T-cell Co-stimulator

• Cat.No.: Icos-1747M

Specification

• Cat. No.: Icos-1747M
• Description: Inducible co-stimulator (ICOS) is an inducible homodimeric costimulator protein that is structurally and functionally related to CD28. It is a third member of the CD28/CTLA4 family and it is expressed on activated T cells. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. ICOS is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse ICOS is Mr 44 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 47 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Icos inducible T-cell co-stimulator [ Mus musculus ]
• Synonyms: Icos; inducible T-cell co-stimulator; H4; AILIM; Ly115; OTTMUSP00000002206
• Gene ID: 54167
• mRNA Refseq: NM_017480
• Protein Refseq: NP_059508
• UniProt ID: Q9WVS0
• Chromosome Location: 1 C2; 1 32.0 cM
• Pathway: Cell adhesion molecules (CAMs); Primary immunodeficiency; T cell receptor signaling pathway
• Function: protein binding