Recombinant Mouse Inducible T-cell Co-stimulator Icos-1747M

Recombinant Mouse Inducible T-cell Co-stimulator


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Recombinant Mouse Inducible T-cell Co-stimulator

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Cat.No. : Icos-1747M Optional Service: Optional requirements on this protein
Description : Inducible co-stimulator (ICOS) is an inducible homodimeric costimulator protein that is structurally and functionally related to CD28. It is a third member of the CD28/CTLA4 family and it is expressed on activated T cells. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. ICOS is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.
Molecular Weight : The predicted molecular weight of Recombinant Mouse ICOS is Mr 44 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 47 kDa.
Source : Sf 21 Insect Cells.
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Icos inducible T-cell co-stimulator [ Mus musculus ]
Synonyms : Icos; inducible T-cell co-stimulator; H4; AILIM; Ly115; OTTMUSP00000002206
Gene ID : 54167
mRNA Refseq : NM_017480
Protein Refseq : NP_059508
UniProt ID : Q9WVS0
Chromosome Location : 1 C2; 1 32.0 cM
Pathway : Cell adhesion molecules (CAMs); Primary immunodeficiency; T cell receptor signaling pathway
Function : protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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