Recombinant Mouse Inpp5a Protein, Myc/DDK-tagged

• Cat.No.: Inpp5a-3546M
• Product Overview: Purified recombinant protein of mouse full-length inositol polyphosphate-5-phosphatase A (Inpp5a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 47.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Inpp5a inositol polyphosphate-5-phosphatase A [ Mus musculus (house mouse) ]
• Official Symbol: Inpp5a
• Synonyms: INPP5A; inositol polyphosphate-5-phosphatase A
• Gene ID: 212111
• mRNA Refseq: NM_001127363
• Protein Refseq: NP_001120835
• UniProt ID: Q7TNC9

Reviews

11/27/2021

The product's rapid action in triggering cellular responses significantly expedited our experiments.

08/30/2020

The user-friendly design of the product made it accessible to researchers with varying levels of expertise.

01/11/2019

The availability of technical experts for consultations greatly aided in optimizing our experiments.

Q&As

What is the gene summary of INPP5A according to Entrez?

According to Entrez, the protein encoded by INPP5A is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase.

In what cellular process does INPP5A play a crucial role?

INPP5A plays a crucial role in the survival of cerebellar Purkinje cells.

What type of inositol phosphate does INPP5A hydrolyze?

INPP5A specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.

What is the main function of INPP5A?

INPP5A is a phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.

Can you provide information on the molecular structure of INPP5A?

INPP5A has a specific catalytic domain that is responsible for its phosphatase activity. The structural details of INPP5A are important for understanding its function in inositol phosphate metabolism.

What is the molecular function of INPP5A?

INPP5A functions as a hydrolase.

What is the role of INPP5A in cellular signaling?

INPP5A regulates cellular signaling by controlling the levels of inositol phosphates, which are important secondary messengers in many cellular pathways.