Recombinant Mouse Inpp5k Protein, Myc/DDK-tagged
Cat.No. : | Inpp5k-3550M |
Product Overview : | Purified recombinant protein of mouse full-length inositol polyphosphate 5-phosphatase K (Inpp5k), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 54.2 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Inpp5k inositol polyphosphate 5-phosphatase K [ Mus musculus (house mouse) ] |
Official Symbol : | Inpp5k |
Synonyms : | INPP5K; inositol polyphosphate 5-phosphatase K; PI-5-phosphatase related; putative PI-5-phosphatase; skeletal muscle and kidney-enriched inositol phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; C62; Pps; SKIP |
Gene ID : | 19062 |
mRNA Refseq : | NM_008916 |
Protein Refseq : | NP_032942 |
UniProt ID : | Q8C5L6 |
Products Types
◆ Recombinant Protein | ||
INPP5K-2098R | Recombinant Rhesus Macaque INPP5K Protein, His (Fc)-Avi-tagged | +Inquiry |
INPP5K-5104H | Recombinant Human INPP5K Protein, GST-tagged | +Inquiry |
INPP5K-31407TH | Recombinant Human INPP5K, His-tagged | +Inquiry |
INPP5K-2277R | Recombinant Rhesus monkey INPP5K Protein, His-tagged | +Inquiry |
INPP5K-3300H | Recombinant Human INPP5K protein, His-tagged | +Inquiry |
◆ Lysates | ||
INPP5K-5197HCL | Recombinant Human INPP5K 293 Cell Lysate | +Inquiry |
INPP5K-5196HCL | Recombinant Human INPP5K 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMutations in d-3-PHGDH have been associated with a neurological phenotype that overlaps with Marinesco-Sjögren syndrome and INPP5K disease.
l-serine administration is proposed as a promising therapeutic strategy for patients with d-3-PHGDH mutations.
This study reveals a common core phenotypical feature and a shared molecular mechanism among Marinesco-Sjögren syndrome, INPP5K disease, and d-3-PHGDH mutations.
Alterations in d-3-PHGDH, an enzyme that modulates the production of l-serine, were identified as a common molecular feature.
Six new INPP5K patients were included in this study.
The effect of l-serine was tested in zebrafish models with mutations in sil1, phgdh, and inpp5k a+b genes, which improved their neuronal phenotype.
INPP5K mutations are associated with a rare disorder that shares symptoms with Marinesco-Sjögren syndrome, such as cataracts, myopathy, and ataxia.
Customer Reviews (3)
Write a reviewWe observed minimal changes in results even after prolonged storage, showcasing its long-term stability.
Its reliability over time reduced the need for frequent reordering, saving both time and resources.
The absence of adverse effects on cells or organisms underscored the product's safety and suitability for biological research.
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