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Recombinant Mouse Inpp5k Protein, Myc/DDK-tagged

Cat.No. : Inpp5k-3550M
Product Overview : Purified recombinant protein of mouse full-length inositol polyphosphate 5-phosphatase K (Inpp5k), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 54.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Inpp5k inositol polyphosphate 5-phosphatase K [ Mus musculus (house mouse) ]
Official Symbol : Inpp5k
Synonyms : INPP5K; inositol polyphosphate 5-phosphatase K; PI-5-phosphatase related; putative PI-5-phosphatase; skeletal muscle and kidney-enriched inositol phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; C62; Pps; SKIP
Gene ID : 19062
mRNA Refseq : NM_008916
Protein Refseq : NP_032942
UniProt ID : Q8C5L6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the clinical significance of d-3-PHGDH alterations? 10/09/2022

Mutations in d-3-PHGDH have been associated with a neurological phenotype that overlaps with Marinesco-Sjögren syndrome and INPP5K disease.

What potential therapeutic strategy is mentioned for patients with d-3-PHGDH mutations? 09/12/2022

l-serine administration is proposed as a promising therapeutic strategy for patients with d-3-PHGDH mutations.

What does this study reveal about the three rare diseases under investigation? 03/22/2022

This study reveals a common core phenotypical feature and a shared molecular mechanism among Marinesco-Sjögren syndrome, INPP5K disease, and d-3-PHGDH mutations.

What common molecular feature was identified in both Marinesco-Sjögren syndrome and INPP5K patients? 01/20/2022

Alterations in d-3-PHGDH, an enzyme that modulates the production of l-serine, were identified as a common molecular feature.

How many new INPP5K patients were included in this study? 08/10/2020

Six new INPP5K patients were included in this study.

How was the effect of l-serine tested in this study? 05/11/2018

The effect of l-serine was tested in zebrafish models with mutations in sil1, phgdh, and inpp5k a+b genes, which improved their neuronal phenotype.

What disorders are associated with INPP5K mutations? 02/08/2018

INPP5K mutations are associated with a rare disorder that shares symptoms with Marinesco-Sjögren syndrome, such as cataracts, myopathy, and ataxia.

Customer Reviews (3)

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Reviews
04/06/2022

    We observed minimal changes in results even after prolonged storage, showcasing its long-term stability.

    10/28/2019

      Its reliability over time reduced the need for frequent reordering, saving both time and resources.

      04/01/2017

        The absence of adverse effects on cells or organisms underscored the product's safety and suitability for biological research.

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