Recombinant Mouse Intu Protein, Myc/DDK-tagged

• Cat.No.: Intu-3559M
• Product Overview: Purified recombinant protein of mouse full-length inturned planar cell polarity protein (Intu), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 104.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Intu inturned planar cell polarity protein [ Mus musculus (house mouse) ]
• Official Symbol: Intu
• Synonyms: Intu; inturned planar cell polarity protein; Pdzd; Pdzk; Pdzd6; Pdzk6; mKIAA1284; 9230116I04Rik; 9430087H23Rik; protein inturned; PDZ domain-containing protein 6; inturned planar cell polarity effector homolog
• Gene ID: 380614
• mRNA Refseq: NM_175515
• Protein Refseq: NP_780724
• UniProt ID: Q059U7