Recombinant Mouse Kat2b Protein, Myc/DDK-tagged

• Cat.No.: Kat2b-3644M
• Product Overview: Purified recombinant protein of mouse full-length K(lysine) acetyltransferase 2B (Kat2b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Also acetylates spermidine.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 92.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kat2b K(lysine) acetyltransferase 2B [ Mus musculus (house mouse) ]
• Official Symbol: Kat2b
• Synonyms: KAT2B; K(lysine) acetyltransferase 2B; histone acetyltransferase KAT2B; histone acetylase PCAF; p300/CBP-associated factor; lysine acetyltransferase 2B; histone acetyltransferase PCAF; Pcaf; p/CAF; AI461839; AW536563; A930006P13Rik
• Gene ID: 18519
• mRNA Refseq: NM_020005
• Protein Refseq: NP_064389
• UniProt ID: Q9JHD1