Recombinant Mouse Kctd11 Protein, Myc/DDK-tagged

• Cat.No.: Kctd11-3665M
• Product Overview: Purified recombinant protein of mouse full-length potassium channel tetramerisation domain containing 11 (Kctd11), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 26.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kctd11 potassium channel tetramerisation domain containing 11 [ Mus musculus (house mouse) ]
• Official Symbol: Kctd11
• Synonyms: KCTD11; potassium channel tetramerisation domain containing 11; BTB/POZ domain-containing protein KCTD11; retinoic acid, EGF, and NGF upregulated; Ren; AF465352
• Gene ID: 216858
• mRNA Refseq: NM_153143
• Protein Refseq: NP_694783
• UniProt ID: Q8K485