Recombinant Mouse Kpna2 Protein, MYC/DDK-tagged Kpna2-1279M

Recombinant Mouse Kpna2 Protein, MYC/DDK-tagged

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Recombinant Mouse Kpna2 Protein, MYC/DDK-tagged

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Cat.No. : Kpna2-1279M
Product Overview : Purified recombinant protein of full-length mouse karyopherin (importin) alpha 2 (cDNA clone MGC:91246 IMAGE:6334979), complete cds, with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
Description : Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 48 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Kpna2 karyopherin (importin) alpha 2 [ Mus musculus (house mouse) ]
Official Symbol : Kpna2
Synonyms : Kpna2; karyopherin (importin) alpha 2; Rch1; IPOA1; PTAC58; 2410044B12Rik; importin subunit alpha-1; RAG cohort protein 1; SRP1-alpha; importin alpha 1; importin alpha P1; importin subunit alpha-2; karyopherin subunit alpha-2; m-importin-alpha-P1; pendulin; pore targeting complex 58 kDa subunit
Gene ID : 16647
mRNA Refseq : NM_010655
Protein Refseq : NP_034785
UniProt ID : P52293

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