Recombinant Mouse L3mbtl2 Protein, Myc/DDK-tagged

• Cat.No.: L3mbtl2-3744M
• Product Overview: Purified recombinant protein of mouse full-length L3MBTL2 polycomb repressive complex 1 subunit (L3mbtl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 79.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: L3mbtl2 L3MBTL2 polycomb repressive complex 1 subunit [ Mus musculus (house mouse) ]
• Official Symbol: L3mbtl2
• Synonyms: L3MBTL2; l(3)mbt-like 2 (Drosophila); lethal(3)malignant brain tumor-like protein 2; l(3)mbt-like protein 2; M4mbt; 4732493N06Rik; MGC31247
• Gene ID: 214669
• mRNA Refseq: NM_145993
• Protein Refseq: NP_666105
• UniProt ID: P59178

Reviews

03/22/2021

They are readily available to address any concerns or questions and supply valuable resources to assist in experimental design and optimization.

08/06/2019

Their expertise in protein production and purification ensures the delivery of a high-quality product that consistently performs well in my experiments.

09/23/2018

Should I encounter any challenges or require technical assistance, the manufacturer provides prompt and knowledgeable support.

Q&As

In what ways does L3MBTL2 interact with other cellular proteins?

L3MBTL2 interacts with various proteins involved in chromatin remodeling and gene regulation, highlighting its role in complex cellular networks.

How does L3MBTL2 impact cellular differentiation?

L3MBTL2 has been implicated in cellular differentiation processes, influencing the fate of stem cells and contributing to tissue development.

Are there any known mutations in the L3MBTL2 gene associated with human diseases?

Some studies suggest that mutations in the L3MBTL2 gene may contribute to certain human diseases, including cancer and developmental disorders.

How is the expression of L3MBTL2 regulated in human cells?

The expression of L3MBTL2 is tightly regulated at the transcriptional and post-transcriptional levels, influencing its cellular functions.

Can L3MBTL2 be a potential therapeutic target in cancer treatment?

The role of L3MBTL2 in cancer suggests it could be a promising therapeutic target, but further research is needed to explore its potential in clinical applications.