Recombinant Mouse Lamtor5 Protein, Myc/DDK-tagged

• Cat.No.: Lamtor5-3363M
• Product Overview: Purified recombinant protein of mouse full-length hepatitis B virus x interacting protein (cDNA clone MGC:41446 IMAGE:1513442), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 9.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [ Mus musculus (house mouse) ]
• Official Symbol: Lamtor5
• Synonyms: Lamtor5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5; Hbx; XIP; Hbxip; 1110003H18Rik; ragulator complex protein LAMTOR5; HBV X-interacting protein homolog; HBX-interacting protein homolog; hepatitis B virus X-interacting protein homolog; hepatitis B virus x interacting protein; late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
• Gene ID: 68576
• mRNA Refseq: NM_026774
• Protein Refseq: NP_081050
• UniProt ID: Q9D1L9