Recombinant Mouse Lgals8 Protein, Myc/DDK-tagged

• Cat.No.: Lgals8-3776M
• Product Overview: Purified recombinant protein of mouse full-length lectin, galactose binding, soluble 8 (Lgals8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 36.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Lgals8 lectin, galactose binding, soluble 8 [ Mus musculus (house mouse) ]
• Official Symbol: Lgals8
• Synonyms: LGALS8; lectin, galactose binding, soluble 8; galectin-8; gal-8; galectin 8; galectin-8L; lectin, galactose binding, soluble 5; Lgals-8; AI326142; D13Ertd524e; 1200015E08Rik
• Gene ID: 56048
• mRNA Refseq: NM_018886
• Protein Refseq: NP_061374
• UniProt ID: Q9JL15