Recombinant Mouse Limd1 Protein, Myc/DDK-tagged

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Recombinant Mouse Limd1 Protein, Myc/DDK-tagged

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Cat.No. : Limd1-3783M
Product Overview : Purified recombinant protein of mouse full-length LIM domains containing 1 (Limd1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 71.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Limd1 LIM domains containing 1 [ Mus musculus (house mouse) ]
Official Symbol : Limd1
Synonyms : LIMD1; LIM domains containing 1; LIM domain-containing protein 1; AW822033; D9Ertd192e
Gene ID : 29806
mRNA Refseq : NM_013860
Protein Refseq : NP_038888
UniProt ID : Q9QXD8

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