Recombinant Mouse Litaf Protein, Myc/DDK-tagged

• Cat.No.: Litaf-3792M
• Product Overview: Purified recombinant protein of mouse full-length LPS-induced TN factor (Litaf), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 16.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Litaf LPS-induced TN factor [ Mus musculus (house mouse) ]
• Official Symbol: Litaf
• Synonyms: LITAF; LPS-induced TN factor; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; mEET; LITAF-like protein; Nedd4 WW domain-binding protein 3; LPS-induced TNF-alpha factor homolog; estrogen-enhanced transcript protein; TBX1; C85531; N4WBP3; 3222402J11Rik
• Gene ID: 56722
• mRNA Refseq: NM_019980
• Protein Refseq: NP_064364
• UniProt ID: Q9JLJ0