| Description : |
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. |
| Source : |
HEK293T |
| Species : |
Mouse |
| Tag : |
C-MYC/DDK |
| Molecular Mass : |
178.6 kDa |
| Protein Length : |
Full Length |
| AA Sequence : |
MRRPGLGGPCPLLLLLLLPAATSAS GSSPSPSPSPIEKAVVPSHQAGVAA CHCCLDQTPKSSRCTRASCRVRNCP PAKCTGLEGCLTPTPSVPSPSRSPV EKSQVSLNWQPLTLQEARALLRQRR PRGPWARALLKRRPPHRAPAGQARV LCPLICHNGGVCVKPDRCLCPPDFA GKFCQLHSSGARPPAPAMPGLTRSV YTMPLANHRDDEHGVASMVSVHVEH PQEASVVVHQVERVSGPWEEANPEA LARAEAAARAEAAAPYTVLAQSAPR EDGYSDASGFGYCFRELRGSECASP LPGLRTQEVCCRGEGLAWGVHDCHP CAEHLRNSNQVSGPNGPCPPGFERV NGSCVDVDECATGGRCQHGECANTR GGYTCVCPDGFLLDSSRSSCISQHV ISEAKGPCYRVLHDGGCSLPILRNI TKQICCCSRVGKAWGRGCQLCPPYG SEGFREICPAGPGYHYSASDLRYNT RPLNQDPPRVTFNQPRVPPATPRPP TGFLPTRRPEPRPDPGPQPEPRPRP EPRPRPESRPRPEPRPRPEPRPQPE SQPRPESRPRPESQPWPEFPLPSIP AWTGPEIPESGPSSSMCQRNPQVCG PGRCVPRPSGYTCACDPGFRLGPQG TRCIDIDECRRVPTPCAPGRCENTP GSFRCVCGTGFQAGPRATECLDVDE CRRVPPPCDRGRCENTPGSFLCVCP AGYQAAPHGASCQDVDECTQSPGLC GRGVCENLPGSFRCVCPAGFRGSAC EEDVDECAQQPPPCGPGRCDNTAGS FHCACPAGFRSRGPGAPCQDVDECS RSPSPCAYGRCENTEGSFKCVCPTG FQPNAAGSECEDVDECENRLACPGQ ECVNSPGSFQCRACPVGHHLHRGRC TDVDECSSGTPCGLHGQCTNTKGSF HCSCSTGYRAPSGQPGPCADINECL EGDFCFPHGECLNTDGSFTCTCAPG YRPGPRGASCLDVDECSEEDLCQSG ICTNTDGSFECICPPGHRAGPDLAS CLDIDECRERGPALCGSQRCENSPG SYRCVRDCDPGYHPGPEGTCDDIDE CREYGSAICGAQRCENTPGSYRCTP ACDPGYQPTPGGGCQDVDECRNRSF CGAHAMCQNLPGSFQCVCDQGYEGA RDGRHCVDVNECETLQGVCGSALCE NVEGSFLCVCPNSPEEFDPMTGRCV PPRAPAGTFPGSQPQAPASPSLPAR PPAPPPPRRPSPPRQGPVSSGRREC YFDTAAPDACDNILARNVTWQECCC TVGEGWGSGCRIQQCPGTETAEYQS LCPHGRGYLVPSGDLSARRDVDECQ LFQDQVCKSGVCVNTAPGYSCYCSN GFYYHAHRLECVDNDECADEEPACE GGRCVNTVGSYHCTCEPPLVLDGSR RRCVSNESQSLDDNLGVCWQEVGPD LVCSRPRLDRQATYTECCCLYGEAW GMDCALCPAQDSDDFEALCNVLRPP AYGPPRPGGFGIPYEYGPDIGPPYQ SLPYGPDLYPPPVLPYDPYPPPPGP FARREAPYGAPPFDMPDFEDDGGPY GESETPDPPSRGTGWPYRSRDTRGS FPEPEESSERGSYTGALSEPYEGLE AEECGILDGCPHGRCVRVPEGFTCD CFDGYRLDITRMSCVDVNECDEAEA TSPLCVNARCVNTDGSFRCICRPGF APTHQPHHCAPARPRATRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80 % as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade after receiving vials. |
| Concentration : |
> 0.05 μg/μL as determined by Bradford protein assay method. |
| Storage Buffer : |
50mM Tris.HCl, pH7.5, 100mM glycine, 10 % glycerol. |
