Recombinant Mouse Mesdc2 protein, His-tagged

• Cat.No.: Mesdc2-199M
• Product Overview: Recombinant mouse MESDC2, fused to His-tag at N-terminus was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Description: MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation.
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol
• Molecular Mass: 24.4kDa (218aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESILKMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGGGSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRRE?
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: Mesdc2 mesoderm development candidate 2 [ Mus musculus ]
• Official Symbol: Mesdc2
• Synonyms: MESDC2; mesoderm development candidate 2; LDLR chaperone MESD; msd; mesd; AW537813; mKIAA0081; 2210015O11Rik; MGC25959
• Gene ID: 67943
• mRNA Refseq: NM_023403
• Protein Refseq: NP_075892
• Function: low-density lipoprotein particle receptor binding