Recombinant Mouse Micu1 Protein, Myc/DDK-tagged

• Cat.No.: Micu1-4068M
• Product Overview: Purified recombinant protein of mouse full-length mitochondrial calcium uptake 1 (Micu1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 54.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Micu1 mitochondrial calcium uptake 1 [ Mus musculus (house mouse) ]
• Official Symbol: Micu1
• Synonyms: MICU1; mitochondrial calcium uptake 1; calcium uptake protein 1, mitochondrial; calcium binding atopy-related autoantigen 1; calcium-binding atopy-related autoantigen 1 homolog; Calc; Cbara1; C730016L05Rik; MGC29229; MGC36365; MGC36503; MGC36634
• Gene ID: 216001
• mRNA Refseq: NM_144822
• Protein Refseq: NP_659071
• UniProt ID: Q8VCX5