Recombinant Mouse Mog Protein (Gln29-Gly125), N-His tagged

• Cat.No.: Mog-6755M
• Product Overview: Recombinant mouse Mog (Gln29-Gly125) fused with the N-His tag was expressed in E. coli.

Specification

• Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to act upstream of or within cell adhesion. Located in myelin sheath. Is expressed in brain and cerebellum. Human ortholog (s) of this gene implicated in multiple sclerosis; narcolepsy; and optic neuritis. Orthologous to human MOG (myelin oligodendrocyte glycoprotein).
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 31.85 kDa
• Protein length: Gln29-Gly125
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: Mog myelin oligodendrocyte glycoprotein [ Mus musculus (house mouse) ]
• Official Symbol: Mog
• Synonyms: Mog; myelin oligodendrocyte glycoprotein; B230317G11Rik; myelin-oligodendrocyte glycoprotein
• Gene ID: 17441
• mRNA Refseq: NM_010814
• Protein Refseq: NP_034944
• UniProt ID: Q61885

Reviews

11/20/2022

Excellent in protein studies.

03/14/2022

Reliable, efficient, and effective.

11/23/2021

Worked well, great quality.

Q&As

In which cells or tissues is MOG predominantly expressed?

MOG is predominantly expressed on the outer surface of the myelin sheath in the central nervous system.

What role does MOG play in autoimmune demyelinating diseases?

MOG is a target in autoimmune demyelinating diseases, where the immune system mistakenly attacks it, damaging the myelin sheath.

What diagnostic or therapeutic strategies involve MOG in the context of demyelinating diseases?

MOG antibody testing helps diagnose and distinguish different demyelinating diseases, and therapies aim to modulate the immune response to prevent MOG attack.

Are there known genetic mutations or alterations in MOG associated with specific neurological conditions?

There are no widely recognized genetic mutations in MOG associated with neurological conditions, but research is ongoing.

How does MOG contribute to the integrity and function of the myelin sheath?

MOG contributes to myelin integrity, aiding in proper nerve signal transmission.

How is MOG implicated in the pathogenesis of Multiple Sclerosis (MS)?

MOG antibodies are found in a subset of MS patients, but their exact role in MS pathogenesis is still under investigation.

What is the primary function of MOG in the nervous system?

MOG is involved in the maintenance and stability of the myelin sheath in the central nervous system.