Recombinant Mouse Mog Protein, His-tagged

• Cat.No.: Mog-01M
• Product Overview: Recombinant Mouse Mog protein, a DNA sequence encoding the extracellular domain of Mouse MOG (NP_034944, Q61885) (aa1-116) was expressed in E. coli with a N-terminal polyhistidine tag.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Protein Length: 1-116 a.a.
• Description: Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.
• Form: Supplied as lyophilized powder or solution of 20 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, pH7.4.
• Molecular Mass: The Predicted molecular weight is ~17kDa. It migrates as an approximately 19kDa band in SDS-PAGE under reducing conditions.
• Purity: Greater than 95% as determined by SDS-PAGE
• Storage: Can be stored at 4℃ short term (1-2 weeks). For long term storage, store at -70℃ for up to twelve months from date of receipt. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended to reconstitute the lyophilized Mouse rMOG in sterile and pre-cooled ddH2O not less than 0.1mg/ml, which can then be further diluted to other aqueous solutions.

Gene Information

• Gene Name: Mog myelin oligodendrocyte glycoprotein [ Mus musculus ]
• Official Symbol: Mog
• Synonyms: MOG; myelin oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein; B230317G11Rik
• Gene ID: 17441
• mRNA Refseq: NM_010814
• Protein Refseq: NP_034944