Recombinant Mouse Mysm1 Protein, Myc/DDK-tagged

• Cat.No.: Mysm1-4263M
• Product Overview: Purified recombinant protein of mouse full-length myb-like, SWIRM and MPN domains 1 (Mysm1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis and lymphocyte differentiation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 93.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mysm1 myb-like, SWIRM and MPN domains 1 [ Mus musculus (house mouse) ]
• Official Symbol: Mysm1
• Synonyms: MYSM1; myb-like, SWIRM and MPN domains 1; histone H2A deubiquitinase MYSM1; 2A-DUB; myb-like, SWIRM and MPN domain-containing protein 1; C130067A03Rik; C530050H10Rik; RP23-135A21.2
• Gene ID: 320713
• mRNA Refseq: NM_177239
• Protein Refseq: NP_796213
• UniProt ID: Q69Z66