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Recombinant Mouse NGFR Protein, Fc-tagged

Cat.No.: NGFR-940M
Product Overview: Recombinant extracellular domain of mouse NGFR (Q9Z0W1) (Met 1-Asn 243) was fused with the Fc region of human IgG1 at the C-terminus.
Source: HEK293
Species: Mouse
Tag: Fc
Predicted N Terminal: Lys 22
Form: Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol.
Bio-activity: Measured by its ability to inhibit NGF dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.5-3 μg/mL in the presence of 2 ng/mL Recombinant mouse NGF.
Molecular Mass: The secreted recombinant mouse NGFR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 463 amino acids and has a calculated molecular mass of 50.6 kDa. The apparent molecular mass of rmNGFR/Fc monomer is approximately 70-80 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Purity: >90 % as determined by SDS-PAGE.
Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name: Ngfr nerve growth factor receptor (TNFR superfamily, member 16) [ Mus musculus ]
Official Symbol: NGFR
Synonyms: NGFR; nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16; NGF receptor; p75 neurotrophin receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; p75; LNG
Gene ID: 18053
mRNA Refseq: NM_033217
Protein Refseq: NP_150086
MIM:
UniProt ID:
Pathway: Axonal growth inhibition (RHOA activation), organism-specific biosystem; Axonal growth stimulation, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Ceramide signalling, organism-specific biosystem;
Function: beta-amyloid binding; death receptor activity; nerve growth factor binding; nerve growth factor binding; neurotrophin TRKA receptor binding; neurotrophin-3 binding; preprotein binding; protein binding; receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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