Recombinant Mouse Nkiras2 Protein, Myc/DDK-tagged

• Cat.No.: Nkiras2-4422M
• Product Overview: Purified recombinant protein of mouse full-length NFKB inhibitor interacting Ras-like protein 2 (Nkiras2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 21.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nkiras2 NFKB inhibitor interacting Ras-like protein 2 [ Mus musculus (house mouse) ]
• Official Symbol: Nkiras2
• Synonyms: NKIRAS2; NFKB inhibitor interacting Ras-like protein 2; NF-kappa-B inhibitor-interacting Ras-like protein 2; kappaB-Ras2; kappa B-Ras protein 2; I-kappa-B-interacting Ras-like protein 2; KBRAS2; 2410003M04Rik; 4930527H08Rik; D630018G21Rik
• Gene ID: 71966
• mRNA Refseq: NM_028024
• Protein Refseq: NP_082300
• UniProt ID: Q9CR56