Recombinant Mouse Nrde2 Protein, Myc/DDK-tagged

• Cat.No.: Nrde2-1831M
• Product Overview: Purified recombinant protein of mouse full-length cDNA sequence BC002230 (cDNA clone MGC:38228 IMAGE:5323598), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm.
• Molecular Mass: 86.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nrde2 nrde-2 necessary for RNA interference, domain containing [ Mus musculus (house mouse) ]
• Official Symbol: Nrde2
• Synonyms: Nrde2; nrde-2 necessary for RNA interference, domain containing; 6720454P05Rik; nuclear exosome regulator NRDE2; UPF0614 protein C14orf102 homolog; protein NRDE2 homolog
• Gene ID: 217827
• mRNA Refseq: NM_001290303
• Protein Refseq: NP_001277232
• UniProt ID: Q80XC6