|Product Overview:||Mouse NRP1, Mouse IgG2a Fc Tag is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Pro 856 (Accession # P97333-1).|
|Description:||Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.|
|Predicted N Terminal:||Phe 22|
|Form:||Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose.|
|Molecular Mass:||This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 120.5 kDa. The protein migrates as 125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length:||Phe 22 - Pro 856|
|Endotoxin:||Less than 1.0 EU per μg by the LAL method.|
|Purity:||>90% as determined by SDS-PAGE.|
|Storage:||For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss is observed after storage at:
4-8°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
|Reconstitution:||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|Gene Name:||Nrp1 neuropilin 1 [ Mus musculus (house mouse) ]|
|Synonyms:||Nrp; NP-1; Npn1; NPN-1; C530029I03; A5 protein; Neuropilin-1 precursor (A5 protein); transmembrane receptor; neuropilin-1|