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Recombinant Mouse Nt5e protein, His-tagged

Cat.No. : Nt5e-6720M
Product Overview : Recombinant Mouse Nt5e aa. (Trp29~phe550 (Accession # Q61503)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a membrane-bound nucleotidase that hydrolyzes extracellular nucleoside monophosphates. The encoded preproprotein undergoes proteolytic processing to generate to a functional, homodimeric enzyme that preferentially uses adenosine monophosphate as a substrate to generate free adenosine. Mice lacking the encoded protein exhibit a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow.
Source : E. coli
Species : Mouse
Tag : His
Form : Freeze-dried powder
Molecular Mass : 60kDa as determined by SDS-PAGE reducing conditions.
Protein length : Trp29~phe550 (Accession # Q61503)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as liquid form in Phosphate buffered saline(PBS), pH 7.4.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Nt5e 5' nucleotidase, ecto [ Mus musculus (house mouse) ]
Official Symbol : Nt5e
Synonyms : NT; Nt5; eNT; CD73; 5'-NT; AI447961; 2210401F01Rik; ecto-5'-nucleotidase; 5'-nucleotidase
Gene ID : 23959
mRNA Refseq : NM_011851.4
Protein Refseq : NP_035981.1
UniProt ID : Q61503

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can NT5E be used as a biomarker for certain diseases? 03/22/2023

Yes, elevated levels of NT5E have been observed in various diseases, making it a potential biomarker for conditions such as cancer and autoimmune disorders.

How does NT5E contribute to inflammation? 11/02/2022

NT5E-generated adenosine has anti-inflammatory effects, and modulating NT5E activity is being explored as a potential therapeutic strategy for inflammatory conditions.

Is NT5E associated with autoimmune diseases? 05/26/2021

Yes, NT5E is implicated in autoimmune diseases, and targeting its activity is being investigated for potential therapeutic interventions.

Are there any FDA-approved drugs targeting NT5E for cancer treatment? 03/10/2020

As of my last knowledge update in January 2022, there were no FDA-approved drugs specifically targeting NT5E, but research in this area is ongoing.

How is NT5E linked to neurological disorders? 12/11/2017

NT5E-generated adenosine is neuroprotective, and research is exploring its potential in the treatment of neurodegenerative disorders.

Customer Reviews (3)

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Reviews
11/20/2022

    the manufacturer's support plays a crucial role in the successful implementation of trials involving the NT5E protein.

    09/01/2017

      The manufacturer maintains stringent quality control measures to ensure the purity and stability of the protein, minimizing experimental variability and maximizing the accuracy of the data obtained.

      01/25/2017

        Their responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.

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