Recombinant Mouse Nudt1 Protein, Myc/DDK-tagged

• Cat.No.: Nudt1-4532M
• Product Overview: Purified recombinant protein of mouse full-length nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Antimutagenic Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity Binds U8 snoRNA
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 18.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 [ Mus musculus (house mouse) ]
• Official Symbol: Nudt1
• Synonyms: NUDT1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; nudix motif 1; 2-hydroxy-dATP diphosphatase; 8-oxo-7,8-dihydro-2-dGTPase; mutT human homolog (8-oxo-dGTPase); nucleoside diphosphate-linked moiety X motif 1; Mth1
• Gene ID: 17766
• mRNA Refseq: NM_008637
• Protein Refseq: NP_032663
• UniProt ID: P53368