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Recombinant Mouse OSTM1 Protein, His-tagged

Cat.No. : Ostm1-511M
Product Overview : Recombinant Mouse Ostm1 (NP_766004.1) (Met1-Ser288) was expressed with a polyhistidine tag at the C-terminus.
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Description : Osteopetrosis-ass centigradeiated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 ass centigradeiation with CLCN7 demonstrated that OSTM1 requires CLCN7 to l centigradealize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for oste centigradelast activation. Thus, OSTM1 has a important role in oste centigradelast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to oste centigradelast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).
Source : HEK293
Species : Mouse
Tag : His
Predicted N Terminal : Ala 35
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant mouse Ostm1 consists of 265 amino acids and predicts a molecular mass of 29.7 kDa.
Protein length : Met1-Ser288
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95% as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Ostm1 osteopetrosis associated transmembrane protein 1 [ Mus musculus ]
Official Symbol : Ostm1
Synonyms : OSTM1; osteopetrosis associated transmembrane protein 1; osteopetrosis-associated transmembrane protein 1; grey lethal osteopetrosis; gl; HSPC019; 1200002H13Rik;
Gene ID : 14628
mRNA Refseq : NM_172416
Protein Refseq : NP_766004

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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