Recombinant Mouse Otub1 Protein, MYC/DDK-tagged Otub1-323M

Recombinant Mouse Otub1 Protein, MYC/DDK-tagged

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Recombinant Mouse Otub1 Protein, MYC/DDK-tagged

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Cat.No. : Otub1-323M
Product Overview : Purified recombinant protein of full-length mouse OTU domain, ubiquitin aldehyde binding 1 (Otub1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 31.3 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Otub1 OTU domain, ubiquitin aldehyde binding 1 [ Mus musculus (house mouse) ]
Official Symbol : Otub1
Synonyms : Otub1; OTU domain, ubiquitin aldehyde binding 1; AI850305; ubiquitin thioesterase OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; deubiquitinating enzyme OTUB1; otubain 1; ubiquitin-specific-processing protease OTUB1; EC 3.4.19.12
Gene ID : 107260
mRNA Refseq : NM_134150
Protein Refseq : NP_598911
UniProt ID : Q7TQI3

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