Recombinant Mouse Pdzk1 Protein, Myc/DDK-tagged

• Cat.No.: Pdzk1-4784M
• Product Overview: Purified recombinant protein of mouse full-length PDZ domain containing 1 (Pdzk1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
• Molecular Mass: 56.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pdzk1 PDZ domain containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Pdzk1
• Synonyms: PDZK1; PDZ domain containing 1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; NHERF-3; naPi-Cap1; PDZ domain-containing protein 1; CFTR-associated protein of 70 kDa; Na(+)/H(+) exchanger regulatory factor 3; sodium-hydrogen exchanger regulatory factor 3; na/Pi cotransporter C-terminal-associated protein 1; Pdzd1; mPDZK1; AI267131; AI314638; AL022680; D3Ertd537e; 1700023D20Rik; 2610507N21Rik; 4921513F16Rik
• Gene ID: 59020
• mRNA Refseq: NM_021517
• Protein Refseq: NP_067492
• UniProt ID: Q9JIL4