Recombinant Mouse Pea15a Protein, Myc/DDK-tagged

• Cat.No.: Pea15a-4786M
• Product Overview: Purified recombinant protein of mouse full-length phosphoprotein enriched in astrocytes 15A (Pea15a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
• Molecular Mass: 15.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pea15a phosphoprotein enriched in astrocytes 15A [ Mus musculus (house mouse) ]
• Official Symbol: Pea15a
• Synonyms: Pea15a; phosphoprotein enriched in astrocytes 15A; Mat; Pea; Mat1; PEA-; Pkcs; Pea15; PEA-15; Pkcs15; astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes; mammary transforming gene 1; phosphoprotein enriched in astrocytes 15
• Gene ID: 18611
• mRNA Refseq: NM_011063
• Protein Refseq: NP_035193
• UniProt ID: Q62048