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Recombinant Mouse Phb Protein, Myc/DDK-tagged

Cat.No. : Phb-4832M
Product Overview : Purified recombinant protein of mouse full-length prohibitin (Phb), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 30.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Phb prohibitin [ Mus musculus (house mouse) ]
Official Symbol : Phb
Synonyms : PHB; prohibitin; B-cell receptor-associated protein 32; Bap32
Gene ID : 18673
mRNA Refseq : NM_008831
Protein Refseq : NP_032857
UniProt ID : P67778

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of PHB proteins in cell signaling? 11/02/2022

PHB proteins play an important role in cell signal transduction. It can act as a regulator of signal transduction pathways, influencing processes such as cell proliferation, differentiation, and apoptosis. The specific mechanism of action needs to be further studied.

How can I detect the expression level of PHB protein? 04/16/2022

The expression level of PHB protein can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of PHB proteins in tissues or cells to assess changes in their expression in disease.

Where is PHB protein located in cells? 10/21/2021

PHB proteins are mainly localized in the inner mitochondrial membrane and nucleus. It plays a role in regulating mitochondrial function and structure on the inner mitochondrial membrane and is involved in processes such as gene transcription and DNA damage repair in the nucleus.

What are the biological functions of PHB proteins? 08/24/2020

PHB proteins have a variety of biological functions. It is involved in mitochondrial biogenesis and regulates mitochondrial number and function, participates in the process of cell proliferation and apoptosis, affects cell growth and death, and also participates in nuclear activities such as gene transcription and DNA damage repair.

What are the therapeutic strategies for PHB protein? 03/26/2020

Therapeutic strategies for PHB proteins include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against PHB proteins to inhibit their aberrant activity in diseases, or the regulation of PHB protein expression through gene knockout or overexpression techniques.

Are interactions between PHB proteins and other proteins present? 12/02/2019

There is an interaction between PHB protein and other proteins. It can interact with mitochondria-related proteins to regulate mitochondrial function and structure, and can also interact with nucleus-related proteins to participate in processes such as gene transcription and DNA damage repair.

Customer Reviews (3)

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Reviews
08/12/2023

    The catalytic activity is amazing, and the mild nature of the mild nature is appreciated for the highly efficient catalysis achieved under mild conditions.

    06/16/2023

      We like the purity and precision of their products, and the results are accurate and reliable.

      07/03/2021

        Their protein production process is strictly controlled, and the quality of products is guaranteed.

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